ALMA MATER STUDIORUM 
University of Bologna
CIRB
CORSO DI LAUREA IN BIOTECNOLOGIE

European Science Foundation
INTEGRATED APPROACHES FOR  
FUNCTIONAL GENOMICS
ACCADEMIA NAZIONALE DEI LINCEI
FIRB per la Bioinformatica (MIUR)
CIB            CNR          INBB
MARINO GOLINELLI FOUNDATION  O.N.L.U.S.

ORGANISATION: AIRBBC (Associazione Italiana per la Ricerca in Biofisica e Biologia Computazionale)		

4th BOLOGNA WINTER SCHOOL on Biotechnology
HOT TOPICS IN  
STRUCTURAL GENOMICS

9-15 February 2003
Department of Biochemistry, Via Irnerio 48, BOLOGNA (Italy) 

TEACHERS:
Patrick Aloy (EMBL, Heidelberg, DE), Pierre Baldi (University of California, Irvine, USA), Nir Ben-Tal (Tel Aviv University, IL), Søren Brunak (Technical University of Denmark, Lyngby, DK), Chris Bystroff (Rensselaer Polytechnic Institute, Troy, USA), Raffaele Calogero (University of Torino, IT), Rita Casadio (University of Bologna, IT), Daniel Fischer (Ben Gurion University, Be'er Sheva, IL), Manuela Helmer-Citterich (University Tor Vergata, Roma, IT), Joel Janin (CNRS, Gif sur Yvette, FR), David Jones (University College, London, UK), Sue Jones (EBI, Hinxton, UK), Arthur Lesk  (University of Cambridge, UK), Henriette Molinari (University of Verona, IT), John Moult (University of Maryland, Rockville, USA), Bruno Samorì (University of Bologna, IT), Jeffrey Skolnick (Buffalo Center of Excellence in Bioinformatics, USA), Mike Taussig (The Babraham Institute, Cambridge, UK), Anna Tramontano (University "La Sapienza", Roma, IT), Alfonso Valencia (National Center of Biotechnology, Cantoblanco, ES), Gunnar von Heijne (University of Stockholm, SE), Richard Wagner (University of Osnabrück, DE), Stephen White (University of California, Irvine, USA). 

SCHOOL CHAIRS: Prof. Rita Casadio (CIRB, AIRBBC), Prof. Lanfranco Masotti (CIRB).

SCIENTIFIC COMMITTEE: R. Casadio, D. Jones, A. Tramontano, A. Valencia.

ORGANIZING COMMITTEE: R. Casadio.

LOCAL COMMITTEE: E. Capriotti, M. Compiani, P. Fariselli, P.L. Martelli, I. Rossi,  G.Tasco.

ORGANIZING SECRETARY:
AIRBBC/CIRB
c/o  Dept. of Biology, University of Bologna
Via Irnerio 42, 40126, Bologna, ITALY. 
Tel: (+39) 051 2094005		Fax: (+39) 051 242576
http://www.biocomp.unibo.it/school/html2003/

For application send a short C.V. to school2003@biocomp.unibo.it 

4th BOLOGNA WINTER SCHOOL 2003: HOT TOPICS IN STRUCTURAL GENOMICS
Bologna, 10-14 February 2003
Dept of Biochemistry, Aula Magna, via Irnerio 48

Monday 10
  8.30 -   9.00	Registration 
  9.00 -   9.10	Opening remarks
  9.10 -  9.30	Mike Taussig: Structural genomics and the ESF program.
  9.30 - 11.00	LINCEI LECTURE: John Moult		 Contemporary Challenges in Structure Prediction
11.00 - 11.30	Coffee Break
11.30 - 13.00	Anna Tramontano	 Comparative modeling techniques: where are we?
	
Lunch
15.00 - 16.30	Jeffrey Skolnick		Prediction of protein structure and function on genomic scale
16.30 - 17.00	Coffee Break
17.00 - 18.30	David Jones		Predicting protein structure: tools, trials and tribulations
Tuesday 11
9.30 - 11.00	David Jones	Neural Networks in structural genomics: a few success stories
11.00 - 11.30	Coffee Break
11.30 - 13.00	Daniel Fischer		Automatic fold recognition prediction, CAFASP, meta-predictors and 3D 
	SHOTGUN
Lunch
15.00 - 16.30	Chris Bystroff		Fully Automated ab initio Protein Structure Prediction Using
	I-SITES, HMMSTR and ROSETTA
16.30 - 17.00	Coffee Break	
17.30 - 18.30	John Moult		The Scope of Structural Genomics
Wednesday 12
  9.30 - 11.00	Arthur Lesk		Prediction of Protein Function
11.00 - 11.30	Coffee Break 
11.30 - 13.00	Raffaele Calogero	Microarray data analysis and mining
Lunch
15.00 - 18.00	ROUND TABLE DISCUSSION: Combining predictions with experiments
	Chairpersons: Arthur Lesk and Anna Tramontano
Speakers: Richard Wagner, Bruno Samorì, Henriette Molinari, Alessandro Desideri
17.00 - 17.30	Coffee Break
Thursday 13 
  9.30 - 10.45	Gunnar von Heijne		Membrane protein topology: from in vivo to in silico
10.45 - 11.15	Coffee Break
11.15 -12.30	Stephen White		MPEx and MPtopo:  Tools for studying membrane protein topology
12.30-13.00	Rita Casadio	Can tools of structural genomics help in membrane protein identification?
Lunch
15.00 - 16.30	Soeren Brunak		Protein feature-based prediction of protein function
16.30 - 17.00	Coffee Break
17.00 – 18.30	 Alfonso Valencia		Protein function prediction: is it feasible?
	Social Dinner

Friday 14
  9.30 - 11.00	Joel Janin		The CAPRI Experiment: Blind prediction of protein-protein complexes
 11.00 - 11.15	Coffee Break 
 11.15 - 12.15 	Patrick Aloy 	The third dimension for protein interactions and complexes
12.15 - 13.15	Manuela Helmer Citterich		Automated analysis of protein surface regions: identification of functional sites for structural genomics
Lunch 
15.30 - 16.30	Sue Jones		Protein-DNA interactions: the story so far and a new method for prediction using 3D structural templates 
16.30 - 17.00	Coffee Break
17.00 - 18.30	Nir Ben Tal		Automatic identification of functional regions in proteins
18.30 - 18.45	Concluding Remarks

Round Table Discussion: Combining predictions with experiments

Alessandro Desideri	Determination of structure and solvent accessibility of transmembrane segments through site-directed spin labeling : the case of the mitochondrial oxoglutarate carrier

Henriette Molinari 		NMR studies of proteins belonging to the Calycin superfamily

Bruno Samorì 					The folding problem: a force spectroscopy approach

Richard Wagner 				Functional screening of membrane proteins by recombinant and electrophysiological techniques

The Poster Section is scheduled in the hall of the building of the school; discussion is encouraged during coffee breaks and round table.